CEACAM6 (CEA cell adhesion molecule 6) is a glycosyl phosphatidyl inositol-anchored cell surface glycoprotein that mediates both homophilic and heterophilic cell adhesion interactions 1. The protein functions in calcium- and fibronectin-independent intercellular adhesion and plays roles in cell migration and neutrophil adhesion to activated endothelial cells 1. CEACAM6 is consistently upregulated across multiple cancer types including pancreatic, breast, lung, gastric, and colorectal cancers, where it promotes tumor progression, invasion, and metastasis through activation of ERK1/2/MAPK and SRC/FAK/PI3K/AKT signaling pathways 2. In colorectal cancer, CEACAM6 activation enhances protein stability through lysine lactylation and controls cell proliferation and chemoresistance 3. The protein serves as an entry portal for adherent-invasive E. coli (AIEC) in inflammatory bowel disease, with expression regulated by JAK-STAT signaling 4. Additionally, CEACAM6 acts as a negative regulator of heme oxygenase-1-mediated antioxidant defense in alveolar epithelial cells, influencing susceptibility to cigarette smoke-induced oxidative stress in COPD 5. These diverse functions establish CEACAM6 as both a valuable diagnostic biomarker and potential therapeutic target across multiple diseases 16.