CEBPD (CCAAT enhancer binding protein delta) is a transcription factor that recognizes CCAAT and enhancer core sequences to regulate gene expression across multiple biological processes 1. As a key regulator of immune and inflammatory responses, CEBPD enhances IL6 transcription both independently and as a heterodimer with CEBPB 2. In cancer biology, CEBPD functions as a master transcriptional regulator of hypoxia-regulated proteins in glioblastoma, where HIF1α and HIF2α activate its promoter 3. CEBPD promotes tumor invasion through the EGFR/PI3K pathway by directly binding and activating fibronectin (FN1) promoter, facilitating extracellular matrix-integrin-mediated signaling 3. The protein also drives enhanced NK cell function against glioblastoma through epigenetic reprogramming and metabolic fitness improvements 4. In autoimmune conditions, CEBPD expression is regulated by the RNA-binding protein Arid5a during IL-17-dependent glomerulonephritis, contributing to inflammatory responses 5. Additionally, CEBPD promotes adipogenesis in white adipose tissue by rapidly upregulating in response to IL-1β stimulation during early differentiation stages 6. Clinical significance includes associations with poor prognosis in glioblastoma and potential therapeutic targeting in various cancers and inflammatory diseases.