CEBPZ (CCAAT enhancer binding protein zeta) is a nucleolar protein with dual roles in ribosomal RNA (rRNA) processing and transcriptional regulation. As the vertebrate homolog of Drosophila NOC1, CEBPZ is essential for rRNA maturation and processing 12. Depletion of CEBPZ leads to accumulation of unprocessed 45S pre-rRNA, reduced protein synthesis, and inhibited cell growth 1. Beyond rRNA processing, CEBPZ functions as a transcriptional coactivator by recruiting the m6A methyltransferase METTL3 to chr2 at transcriptional start sites of active genes, enhancing mRNA translation through m6A modification 3. CEBPZ also serves as a direct target in liver fibrosis, where baicalein binds CEBPZ to suppress liquid-liquid phase separation and activate the p53/HK2 axis, inducing hepatic stellate cell senescence 4. Clinically, CEBPZ exhibits context-dependent expression patterns across tumor types, suggesting complex roles in cancer biology 12. CEBPZ overexpression is associated with acute myeloid leukaemia maintenance 3, glucocorticoid-associated osteonecrosis 5, advanced colorectal cancer progression 6, and diabetic cardiomyopathy 7, positioning it as a potential therapeutic target across multiple disease contexts.