CENPV (centromere protein V) is a multifunctional scaffolding protein with roles in chromosome 17 and cell motility. As a mitotic protein, CENPV is required for centromere organization, chromosome 17, and cytokinesis 1. Beyond its canonical kinetochore functions, CENPV localizes to primary cilia in interphase where it increases acetylated α-tubulin levels through interaction with the deubiquitylase CYLD 1. CENPV also functions in directional cell migration by associating with stabilized microtubules and activating Src family kinases through SH3 domain interaction, thereby linking cytoskeletal dynamics to cell protrusion 2. CENPV serves as a specific marker of pericentromeric heterochromatin in postmeiotic spermatids and is essential for proper heterochromatin organization during spermatogenesis 3. Clinically, CENPV dysregulation is implicated in disease pathogenesis: it is overexpressed in basal cell carcinoma 1, associates with nonalcoholic fatty liver disease where it negatively correlates with resting memory CD4 T cells 4, and represents a prognostic biomarker in oral squamous cell carcinoma where altered methylation predicts survival 5. These findings establish CENPV as a pleiotropic protein linking mitotic function, ciliogenesis, cell migration, and immune regulation.