CEP170B (centrosomal protein 170B) is a microtubule-binding protein that plays a critical role in regulating microtubule organization and establishing cellular polarity. Mechanistically, CEP170B functions as a microtubule minus-end-binding protein that localizes to cortical patches in a liprin-α1-dependent manner 1. CEP170B autonomously tracks growing microtubule minus ends and blocks their growth, and forms a functional complex with the kinesin KIF2A that acts as a potent microtubule minus-end depolymerase 1. By excluding CAMSAP-stabilized microtubule minus ends from the cell periphery, CEP170B contributes to establishing a polarized microtubule network and is required for directional vesicle trafficking and cyst formation in three-dimensional culture 1. Beyond structural roles, CEP170B has been identified as a dysregulated gene in temporal lobe epilepsy, where it interacts with miR-484 and participates in networks affecting neurotransmitter synaptic signaling 2. CEP170B also emerges as a hub gene in shared genetic signatures between epilepsy and glioma, functioning in synaptic signaling and calcium ion pathways with potential diagnostic and prognostic significance 3. These findings position CEP170B as an important regulator of cellular architecture with potential relevance to neurological disease pathogenesis.