CERCAM (cerebral endothelial cell adhesion molecule) is a cell adhesion protein that plays significant roles in multiple pathological processes. In the central nervous system, CERCAM facilitates leukocyte transmigration across the blood-brain barrier, with expression upregulated during Zika virus infection of brain microvascular endothelial cells, contributing to enhanced vascular permeability and barrier dysfunction 1. CERCAM demonstrates oncogenic properties across multiple cancer types, promoting tumor cell proliferation, migration, and invasion through activation of the PI3K/AKT signaling pathway 2. In bladder cancer, CERCAM overexpression correlates with poor prognosis and enhances malignant phenotypes including increased cell viability, DNA synthesis, and invasive capacity 2. Similarly, in head and neck squamous cell carcinoma, elevated CERCAM expression associates with poor prognosis and promotes macrophage M2 polarization within the tumor microenvironment 3. Genetic studies have identified CERCAM as a psoriasis susceptibility gene, with knockout mice showing aggravated dermatitis and elevated T cell retention 4. In colorectal cancer, CERCAM functions as a fibroblast-associated prognostic biomarker, with knockdown significantly impairing malignant phenotypes 5. CERCAM emerges as a potential therapeutic target across multiple diseases due to its diverse pathological functions.