1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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10PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingsperm axoneme assemblyosteoporosisbone diseasealcohol drinkingazoospermia
Based on limited published evidence, CFAP97D1 is required for male fertility through axonemal doublet stabilization essential for sperm motility. The protein is exclusively expressed in testes and functions in sperm flagellum ultrastructure maintenance 1. CFAP97D1 deletion causes asthenozoospermia and male subfertility, with affected sperm displaying abnormal motility and selective loss of the fourth axonemal doublet 1. The gene is evolutionarily conserved across mammalian and other species, including Chlamydomonas.
1
CFAP97D1 is required for flagellar axoneme maintenance and male fertility; its loss causes sperm motility defects, asthenozoospermia, and axonemal doublet heterogeneity with frequent loss of the fourth doublet
PMID: 32785227⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
alcohol drinkingOpen Targets
spermatogenic failure 83Open Targets
spermatogenic failure, X-linked, 5Open Targets
spermatogenic failure 3Open Targets
spermatogenic failure 55Open Targets
spermatogenic failure 84Open Targets
spermatogenic failure 93Open Targets
spermatogenic failure 65Open Targets
spermatogenic failure 72Open Targets
spermatogenic failure 56Open Targets
spermatogenic failure 92Open Targets
spermatogenic failure 94Open Targets
spermatogenic failure 7Open Targets
spermatogenic failure 18Open Targets
spermatogenic failure 27Open Targets
spermatogenic failure 46Open Targets
spermatogenic failure 58Open Targets
No pathogenic variants reported on ClinVar for this gene.