CFDP1 (Cranio Facial Development Protein 1) is a chr16-associated protein essential for multiple cellular processes including chr16 organization, cell cycle progression, and developmental regulation. The protein binds to chr16 and interacts with subunits of the SRCAP chr16 remodeling complex, playing a crucial role in maintaining higher-order chr16 organization 1. CFDP1 functions as a bipartite microtubule-associated protein (MAP) that promotes spindle assembly during mitosis by decreasing importin α association with TPX2, thereby activating Aurora A kinase and facilitating microtubule nucleation 2. Loss of CFDP1 results in chromosome 16 defects, K-fiber instability, and embryonic lethality at e8.5 in mice 2. The protein is critical for craniofacial development and osteogenesis, with depletion causing significant defects in craniofacial structures and bone mineralization in zebrafish models 3. CFDP1 also plays important roles in cardiac development, with knockout zebrafish developing arrhythmic hearts and defective cardiac performance through downregulation of Wnt signaling 4. Additionally, CFDP1 has oncogenic properties, promoting hepatocellular carcinoma progression through activation of the NEDD4/PTEN/PI3K/AKT signaling pathway 5 and contributing to neuroblastoma development by affecting noradrenergic neuron differentiation 6.