CIDEC (Cell Death-Inducing DFFA Like Effector C) is a lipid droplet-associated protein that plays a crucial role in adipose tissue lipid metabolism and energy homeostasis. The protein promotes unilocular lipid droplet formation through mediating lipid droplet fusion, localizing at focal contact sites between droplets and facilitating directional neutral lipid transfer from smaller to larger droplets 1. CIDEC functions as a key regulator of lipolysis by interacting with adipose triglyceride lipase (ATGL) and its activator CGI-58, thereby reducing free fatty acid release and preventing lipotoxicity 2. The protein's expression positively correlates with insulin sensitivity in obese humans, and transgenic mice expressing CIDEC show protection against high-fat diet-induced glucose intolerance 2. CIDEC expression runs parallel to mitochondrial genes in human adipose tissue and increases after bariatric surgery-induced weight loss 3. Disease relevance includes association with familial partial lipodystrophy type 5, where variants like E186X are linked to lipodystrophy, hypertriglyceridemia, and insulin resistance 2. Clinically, CIDEC represents a potential therapeutic target for obesity-induced metabolic disorders, with studies suggesting its use as a 'drug' or 'druggable' target to reverse lipotoxicity and glucose intolerance 2.