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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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CKM
creatine kinase, M-type
Chromosome 19 · 19q13.32
NCBI Gene: 1158Ensembl: ENSG00000104879.6HGNC: HGNC:1994UniProt: B2R892
137PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Kinase
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingcreatine kinase activityphosphocreatine biosynthetic processGO:0005615response to statinintelligenceneurodegenerative diseasegastric ulcer
✦AI Summary

I cannot provide a gene function summary for CKM (creatine kinase, M-type) based on the provided abstracts. The PubMed abstracts exclusively discuss Cardiovascular-Kidney-Metabolic (CKM) syndrome, a clinical disorder defined by the American Heart Association involving the interconnection of cardiovascular disease, type 2 diabetes, and chr19 kidney disease 1. These abstracts do not contain any information about the CKM gene, its protein product, enzymatic function, or molecular mechanisms of creatine kinase activity. To provide an accurate gene function summary grounded in the provided literature, abstracts specifically addressing creatine kinase M-type protein, its phosphate transfer activity, energy metabolism in skeletal muscle and cardiac tissue, or disease associations would be required. The current document set addresses only epidemiology, pathophysiology, and clinical staging of a metabolic syndrome, not the molecular biology of the CKM gene.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
response to statinOpen Targets
0.35Weak
intelligenceOpen Targets
0.23Weak
neurodegenerative diseaseOpen Targets
0.22Weak
gastric ulcerOpen Targets
0.21Weak
malunion fractureOpen Targets
0.20Weak
tuberculosisOpen Targets
0.15Weak
neoplasmOpen Targets
0.10Weak
adverse effectOpen Targets
0.08Suggestive
Abdominal painOpen Targets
0.08Suggestive
HeadacheOpen Targets
0.08Suggestive
Limb painOpen Targets
0.08Suggestive
intrahepatic cholangiocarcinomaOpen Targets
0.07Suggestive
poisoningOpen Targets
0.07Suggestive
response to stimulusOpen Targets
0.07Suggestive
non-alcoholic fatty liver diseaseOpen Targets
0.05Suggestive
dementiaOpen Targets
0.05Suggestive
Duchenne muscular dystrophyOpen Targets
0.04Suggestive
sarcopeniaOpen Targets
0.04Suggestive
cardiovascular diseaseOpen Targets
0.04Suggestive
head injuryOpen Targets
0.03Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
CKBProtein interaction100%GAMTProtein interaction95%MYL1Protein interaction93%MYL2Protein interaction92%ASB9Protein interaction87%CKMT2Protein interaction87%
Tissue Expression6 tissues
Heart
100%
Lung
0%
Liver
0%
Brain
0%
Ovary
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
CKMCKBGAMTMYL1MYL2ASB9CKMT2
PROTEIN STRUCTURE
Preparing viewer…
PDB7BF2 · 1.43 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
1.09LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.79 [0.59–1.09]
RankingsWhere CKM stands among ~20K protein-coding genes
  • #3,368of 20,598
    Most Researched137 · top quartile
  • #11,069of 17,882
    Most Constrained (LOEUF)1.09
Genes detectedCKM
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Cardiovascular-Kidney-Metabolic (CKM) syndrome: A state-of-the-art review.
PMID: 38103820
Curr Probl Cardiol · 2024
1.00
2
Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with Cardiovascular-Kidney-Metabolic syndrome stage 0-3: a nationwide prospective cohort study.
PMID: 39113004
Cardiovasc Diabetol · 2024
0.90
3
Association between systemic immune-inflammation index and cardiovascular-kidney-metabolic syndrome.
PMID: 39160192
Sci Rep · 2024
0.80
4
An overview of cardiovascular-kidney-metabolic syndrome.
PMID: 39705194
Am J Manag Care · 2024
0.70
5
Cardiovascular-kidney-metabolic syndrome - An integrative review.
PMID: 39486671
Prog Cardiovasc Dis · 2024
0.60