CLEC4M (C-type lectin domain family 4 member M) is a cell surface receptor that functions primarily in pathogen recognition and coagulation regulation. As a C-type lectin, CLEC4M serves as a pathogen recognition receptor that can bind various pathogens including SARS-CoV-2, functioning as an ACE2-independent alternative receptor for viral entry 1. The protein recognizes mannose-containing glycans and plays a critical role in coagulation factor homeostasis by serving as a clearance receptor for factor VIII (FVIII) through both von Willebrand factor (VWF)-dependent and independent mechanisms 2. CLEC4M mediates FVIII internalization via clathrin-coated pits, leading to lysosomal degradation 2. Genetic variations in CLEC4M significantly influence VWF levels in type 1 von Willebrand disease patients and affect coagulation factor levels in healthy populations 34. The gene contains a highly polymorphic variable number tandem repeat (VNTR) region that evolved before human migration out of Africa and may influence disease susceptibility 5. Clinical studies have identified associations between CLEC4M polymorphisms and COVID-19 severity, with the rs868875 variant linked to more severe outcomes in patients receiving anticoagulants 6. Additionally, CLEC4M expression levels are elevated in lung cancer patients and may serve as a biomarker for platinum chemotherapy resistance 7.