CLHC1 (clathrin heavy chain linker domain containing 1) is a protein-coding gene located on chromosome 2 with demonstrated protein binding capacity. While CLHC1's precise molecular function remains incompletely characterized, it has emerged as a disease-associated gene through multiple independent studies. CLHC1 was identified as a novel recessive disease gene in neurological disorders through whole-exome sequencing of consanguineous families with neurogenetic phenotypes 1. Beyond neurological relevance, CLHC1 has been identified as a significantly mutated gene in canine mammary tumors, suggesting potential involvement in cancer biology 2. Most notably, CLHC1 has been identified as part of a novel fusion event in human lung adenocarcinoma, where a CLHC1/RNT4 intergenic region fusion with ALK (anaplastic lymphoma kinase) was detected in a patient with brain metastases 3. This ALK fusion patient responded to ALK-targeted therapies including crizotinib and alectinib, indicating that CLHC1-containing fusions may serve as actionable therapeutic targets in NSCLC. These findings suggest CLHC1 participates in both neurodevelopmental and oncogenic pathways, though the specific mechanistic details of its protein function require further investigation.