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GeneE
10 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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CMAS
cytidine monophosphate N-acetylneuraminic acid synthetase
Chromosome 12 · 12p12.1
NCBI Gene: 55907Ensembl: ENSG00000111726.14HGNC: HGNC:18290UniProt: Q8NFW8
97PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
nucleolusmembraneCMP-N-acetylneuraminate biosynthetic processnucleusneurodegenerative diseasehyperpituitarismneuroinflammatory disorderBenign familial chorea
✦AI Summary

I cannot provide a gene function summary for CMAS (cytidine monophosphate N-acetylneuraminic acid synthetase) based on the provided PubMed abstracts. The six abstracts supplied address unrelated topics: global burden of asthma and atopic dermatitis (1), pharmaceutical quality by design methodology (2, 3), smoking prevalence forecasting (4), antibody-peptide conjugates for protein degradation (5), sports injury assessment (6), metabolic activators (7), and global nutrition targets (8). None of these abstracts contain information about CMAS function, sialic acid metabolism, or the enzyme's role in biological processes. To provide an accurate, evidence-based summary of CMAS, abstracts specifically investigating this enzyme's catalytic activity, cellular localization, substrate specificity, or disease associations would be required.

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
neurodegenerative diseaseOpen Targets
0.43Moderate
hyperpituitarismOpen Targets
0.23Weak
neuroinflammatory disorderOpen Targets
0.15Weak
Benign familial choreaOpen Targets
0.05Suggestive
triple-negative breast cancerOpen Targets
0.04Suggestive
HypocalcemiaOpen Targets
0.03Suggestive
cancerOpen Targets
0.03Suggestive
lung adenocarcinomaOpen Targets
0.03Suggestive
infectionOpen Targets
0.02Suggestive
neoplasmOpen Targets
0.02Suggestive
diabetic nephropathyOpen Targets
0.02Suggestive
stomach diseaseOpen Targets
0.02Suggestive
breast cancerOpen Targets
0.02Suggestive
astrocytomaOpen Targets
0.01Suggestive
oligodendrogliomaOpen Targets
0.01Suggestive
congenital rubellaOpen Targets
0.01Suggestive
age-related macular degenerationOpen Targets
0.01Suggestive
fragile X syndromeOpen Targets
0.01Suggestive
SepsisOpen Targets
0.01Suggestive
non-alcoholic fatty liver diseaseOpen Targets
0.01Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
GNEShared pathway100%NANPProtein interaction99%NANSProtein interaction81%SLC35A1Protein interaction67%ST6GAL1Shared pathway17%ST3GAL1Shared pathway11%
Tissue Expression6 tissues
Brain
100%
Bone Marrow
97%
Heart
84%
Liver
82%
Ovary
42%
Lung
29%
Gene Interaction Network
Click a node to explore
CMASGNENANPNANSSLC35A1ST6GAL1ST3GAL1
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted · UniProt Q8NFW8
View on AlphaFold ↗
Constraintⓘ
LOEUFⓘ
0.57Moderately Constrained
pLIⓘ
0.83Intermediate
Observed/Expected LoF0.36 [0.23–0.57]
RankingsWhere CMAS stands among ~20K protein-coding genes
  • #4,927of 20,598
    Most Researched97 · top quartile
  • #3,707of 17,882
    Most Constrained (LOEUF)0.57 · top quartile
Genes detectedCMAS
Sources retrieved10 papers
Response time—
📄 Sources
10▼
1
Global, regional, and national burden of asthma and atopic dermatitis, 1990-2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021.
PMID: 40147466
Lancet Respir Med · 2025
1.00
2
Design of experiments (DoE) in pharmaceutical development.
PMID: 28166428
Drug Dev Ind Pharm · 2017
0.90
3
Understanding pharmaceutical quality by design.
PMID: 24854893
AAPS J · 2014
0.80
4
Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021.
PMID: 39366729
Lancet Public Health · 2024
0.70
5
Targeted Degradation of Cell-Surface Proteins via Chaperone-Mediated Autophagy by Using Peptide-Conjugated Antibodies.
PMID: 38472118
Angew Chem Int Ed Engl · 2024
0.60