Based on limited published evidence, CMKLR2 is a G protein-coupled receptor functioning as an HIV-1 coreceptor. It binds adipokinetic hormone and neuropeptides, participating in neuropeptide signaling and G protein-coupled receptor signaling pathways. CMKLR2 is localized to the plasma membrane and involved in glucose homeostasis and inflammatory response regulation. Additionally, CMKLR2-AS, an antisense transcript overlapping CMKLR2, plays a role in epigenetic regulation of the imprinted gene ZDBF2 in early mammalian development 1.