COL14A1 encodes collagen type XIV alpha 1 chain, a 193.2 kDa protein composed of 1797 amino acids with a signal peptide and mature polypeptide domain structure 1. The protein contains fibronectin type III repeats, von Willebrand factor A domains, thrombospondin-N-terminal-like domains, and two triple-helical domains characteristic of collagen family members 1. COL14A1 plays an adhesive role in extracellular matrix organization by integrating collagen bundles, likely associating with interstitial collagen fibrils via COL1, with its N-terminal globular domain protruding into the extracellular space to interact with matrix molecules and cell surface receptors. In cancer biology, COL14A1 is upregulated in premetastatic lungs exposed to primary breast tumor-derived factors, contributing to ECM remodeling and increased interstitial fibrillar collagen deposition that facilitates metastasis 2. COL14A1 is specifically expressed in inflammatory CAF (iCAF) subtypes within tumors 3. Furthermore, hepatocellular carcinoma-derived circulating cancer stem cells upregulate COL14A1 expression through a hypoxia-responsive pathway involving the HIF-1α/circ-CDYL-EEF1A2 axis, promoting epithelial-mesenchymal transition and lung metastasis 4. In contrast, COL14A1 polymorphisms show no association with Achilles tendon injuries despite the protein's involvement in tendon-related biological processes 5.