CORIN is a type II transmembrane serine protease that serves as a key regulator of blood pressure and electrolyte homeostasis 1. Its primary function is proteolytic activation of atrial natriuretic peptide (ANP) precursor to generate mature ANP, a hormone critical for maintaining electrolyte balance and normal blood pressure 1. CORIN is synthesized as an inactive zymogen requiring proteolytic activation on the cell surface 1. Deficiency in CORIN impairs ANP generation and disrupts electrolyte and body fluid homeostasis 1. Beyond cardiac tissue, CORIN expression occurs in non-cardiac tissues where it participates in diverse physiological processes 1. CORIN variants reducing enzymatic activity have been identified in hypertensive patients 1, and serum corin levels have emerged as a novel serological marker for identifying end-organ damage in hypertensive crisis 2. Additionally, CORIN serves as a floor plate marker for sorting dopaminergic progenitor cells in iPS cell-based regenerative medicine approaches for Parkinson's disease 34. CORIN also functions as a regulator of osteogenic differentiation in bone development 5. Disease associations include familial hypertrophic cardiomyopathy and pre-eclampsia, reflecting its critical role in cardiovascular homeostasis.