CORO7 (coronin 7) is an actin-regulating protein that functions in multiple cellular processes. Structurally, it contains two β-propeller domains and C-terminal Central-Acidic domains 1. Primary to CORO7's function is its role as an Arp2/3 complex branch disassembly factor that promotes actin-dependent ER-Golgi trafficking and maintains Golgi apparatus morphology 1. Additionally, CORO7 serves as a scaffold protein essential for Hippo pathway core kinase complex assembly, regulating cell proliferation and apoptosis through cell-cell contact and cytoskeletal damage sensing 2. Beyond intracellular trafficking, CORO7 participates in metabolic regulation; it is highly expressed in brain regions controlling appetite and energy balance, with expression responsive to feeding states 3. CORO7 dysregulation has clinical significance across multiple diseases. Brain transcriptome-wide association studies identified CORO7 as a schizophrenia risk gene, with dysregulation in dorsolateral prefrontal cortex associated with white matter integrity defects 4. CORO7 expression is upregulated in pancreatic ductal adenocarcinoma 5, and elevated autoantibodies against CORO7 appear in colorectal cancer patients, suggesting potential biomarker utility 6. CORO7 variants also associate with coronary heart disease risk 7. These findings position CORO7 as a multifunctional regulator with implications for metabolic, neuropsychiatric, and cardiovascular disease pathways.