CPSF4 (cleavage and polyadenylation specific factor 4) is a core component of the CPSF complex that mediates pre-mRNA 3'-end formation by recognizing AAUAAA signals and facilitating cleavage and poly(A) addition 1. Beyond its canonical role in mRNA processing, CPSF4 functions as a multifaceted oncogene across multiple cancer types. In hepatocellular carcinoma, elevated CPSF4 expression reduces circRNA levels, disrupting miRNA-mediated gene silencing and promoting tumor proliferation 1. In lung adenocarcinoma and colon cancer, CPSF4 acts as a transcriptional regulator of hTERT, activating telomerase and driving unlimited cell proliferation 23. In triple-negative breast cancer, CPSF4 regulates alternative splicing of HMG20B to enhance cancer cell progression 4. In lung cancer, CPSF4 promotes tumor-initiating phenotypes through VEGF/NRP2/TAZ signaling, conferring chemoresistance 5. Clinical evidence consistently demonstrates that high CPSF4 expression correlates with poor prognosis across cancer types and associates with aggressive features in prostate cancer 6. Additionally, CPSF4 interacts with influenza NS1 protein to suppress interferon-stimulated gene translation, highlighting its role in viral pathogenesis 7. These findings establish CPSF4 as a therapeutic target in cancer treatment.