CTTNBP2NL (CTTNBP2 N-terminal like) is a cytoskeletal regulatory protein that functions as a component of the STRIPAK (striatin-interacting phosphatase and kinase) complex 1. The protein associates with core STRIPAK complex members including striatin, protein phosphatase 2A (PP2A) subunits, and serine/threonine kinases to regulate multiple signaling pathways including Hippo, MAPK, and cytoskeleton remodeling 1. CTTNBP2NL localizes to stress fibers and regulates lamellipodial actin dynamics in a cortactin-dependent manner, with evidence suggesting it functions to stabilize actin branch junctions and modulate actin retrograde flow dynamics 2. Unlike its homolog CTTNBP2, CTTNBP2NL is not predominantly expressed in brain tissue and does not regulate dendritic spinogenesis 3. Regarding disease relevance, CTTNBP2NL deletions have been detected in oral squamous cell carcinoma 4, and genomic breakpoints within CTTNBP2NL have been associated with multiple exostoses and other developmental abnormalities 5. Recent proteomic analysis identified CTTNBP2NL as a differentially expressed protein in obesity-associated endometrial cancer, where elevated expression correlates with inflammatory pathway activation 6. These findings suggest CTTNBP2NL may serve as a biomarker for obesity-driven malignancies.