CXCL14 is a C-X-C motif chemokine that plays diverse roles in immune regulation, cancer biology, and tissue homeostasis. In mucosal immunity, CXCL14 is homeostatically expressed in mucosal tissues and contributes to immune cell recruitment 1. The chemokine demonstrates context-dependent effects in cancer, where tumor cell-specific CXCL14 expression promotes lymphocyte infiltration and suppresses tumor growth in oral squamous cell carcinoma 2. However, CXCL14 can also promote metastasis in lung cancer through ACKR2-dependent signaling pathways involving PLCβ3, PKCα, and NF-κB activation, leading to epithelial-mesenchymal transition 3. In ovarian cancer, CXCL14 mediates stromal-immune cell cross-talk via CXCR4 interactions 4. CXCL14 is expressed by specialized fibroblast populations, including CXCL14+ cancer-associated fibroblasts that contribute to extracellular matrix remodeling and structural barriers in immunotherapy-resistant colorectal cancer 5, and CXCL14-IL24+ secretory fibroblasts associated with tissue remodeling in chr5 nodular prurigo 6. Additionally, CXCL14+ fibroblasts are differentially regulated by cardiovascular risk factors and show associations with atherosclerotic plaque traits 7. In endometriosis, CXCL14 expression by epithelial cells is reduced during the window of implantation 8.