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1 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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CYP3A7-CYP3A51P
CYP3A7-CYP3A51P readthrough
Chromosome 7 · 7q22.1
NCBI Gene: 100861540Ensembl: ENSG00000160870.15HGNC: HGNC:2640UniProt: P24462
5PubMed Papers
20Diseases
2Drugs
0Pathogenic Variants
CLINICAL
FDA Approved Target
DATA QUALITY
✓ Swiss-Prot Reviewed
HIV infectionHIV-1 infectionchronic hepatitis C virus infectionhepatitis C virus infection
✦AI Summary

Based on limited published evidence, CYP3A7-CYP3A51P encodes a cytochrome P450 monooxygenase involved in steroid hormone and vitamin metabolism during embryogenesis 12345. The enzyme catalyzes hydroxylation of carbon-hydrogen bonds using NADPH via cytochrome P450 reductase. It metabolizes DHEA and exhibits high catalytic activity for estrone hydroxylation, particularly at the C16-alpha position 23. CYP3A7-CYP3A51P hydroxylates all-trans-retinoic acid for potential clearance during fetal development 1 and metabolizes xenobiotics including anticonvulsants 5. Genetic variants influence sulfated sex hormone levels 6.

Sources cited
1
Role in steroid hormone and vitamin metabolism during embryogenesis, atRA hydroxylation
PMID: 11093772
2
High catalytic activity for estrone hydroxylation to D-ring hydroxylated estrone
PMID: 12865317
3
Hydroxylation of estrone to C16-alpha hydroxylated estrone
PMID: 14559847
4
DHEA metabolism as steroid hormone biosynthesis precursor
PMID: 17178770
5
DHEA metabolism and xenobiotic metabolism including anticonvulsants
PMID: 9555064
6
Genetic variants modify sulfated sex hormone levels in blood
PMID: 29398597
Disease Associationsⓘ20
HIV infectionOpen Targets
0.61Moderate
HIV-1 infectionOpen Targets
0.59Moderate
chronic hepatitis C virus infectionOpen Targets
0.57Moderate
hepatitis C virus infectionOpen Targets
0.55Moderate
infectionOpen Targets
0.51Moderate
COVID-19Open Targets
0.41Moderate
AIDSOpen Targets
0.41Moderate
viral diseaseOpen Targets
0.37Weak
hepatitis D virus infectionOpen Targets
0.34Weak
cholelithiasisOpen Targets
0.29Weak
menopausal or post-menopausal diseaseOpen Targets
0.28Weak
coronavirus infectious diseaseOpen Targets
0.26Weak
pneumocystosisOpen Targets
0.26Weak
goutOpen Targets
0.25Weak
Kaposi's sarcomaOpen Targets
0.20Weak
Middle East respiratory syndromeOpen Targets
0.18Weak
osteoarthritis, kneeOpen Targets
0.16Weak
intestinal obstructionOpen Targets
0.10Suggestive
long COVID-19Open Targets
0.09Suggestive
ThrombocytopeniaOpen Targets
0.09Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Drug Targets2
COBICISTATApproved
Cytochrome P450 3A inhibitor
HIV-1 infection
RITONAVIRApproved
Cytochrome P450 3A inhibitor
HIV infection
Related Genes
ALDH1A2Protein interaction99%UGT1A4Protein interaction98%UGT1A8Protein interaction98%UGT1A1Protein interaction97%UGT1A7Protein interaction97%UGT1A10Protein interaction97%
Tissue Expression6 tissues
Liver
100%
Lung
4%
Ovary
2%
Bone Marrow
1%
Brain
0%
Heart
0%
Gene Interaction Network
Click a node to explore
CYP3A7-CYP3A51PALDH1A2UGT1A4UGT1A8UGT1A1UGT1A7UGT1A10
PROTEIN STRUCTURE
Preparing viewer…
PDB7MK8 · 2.15 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
1.03LoF Tolerant
pLIⓘ
0.00Tolerant
Observed/Expected LoF0.81 [0.64–1.03]
RankingsWhere CYP3A7-CYP3A51P stands among ~20K protein-coding genes
  • #18,315of 20,598
    Most Researched5
  • #705of 1,025
    FDA-Approved Drug Targets2
  • #10,272of 17,882
    Most Constrained (LOEUF)1.03
Genes detectedCYP3A7-CYP3A51P
Sources retrieved1 papers
Response time—
📄 Sources
1
1
Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones.
PMID: 29398597
EBioMedicine · 2018
1.00