DAAM2 is a formin family protein that serves as a key regulator of Wnt signaling pathways essential for embryonic development and tissue homeostasis. As a downstream effector of Wnt ligands, DAAM2 promotes canonical Wnt signaling by clustering Disheveled complexes and organizing Wnt receptor signalosomes through its association with Rac1 and the actin cytoskeleton 1. DAAM2 also regulates non-canonical Wnt signaling, influencing left/right asymmetry and myocardial maturation 2. The protein functions as an actin nucleator and regulator of filopodia formation and cell migration 3. During central nervous system development, DAAM2 suppresses oligodendrocyte differentiation via PIP5K1A interaction and regulates myelin compaction through Rac1-dependent modulation of Gelsolin levels, promoting ubiquitination and degradation of Gelsolin to control the oligodendrocyte actin cytoskeleton 4. In steroid hormone signaling, DAAM2 localizes to the nucleus where it polymerizes actin at androgen receptors to facilitate transcriptional droplet formation and gene expression 3. Clinically, DAAM2 mutations cause androgen insensitivity syndrome and nephrotic syndrome 24 5. Loss of DAAM2 function correlates with decreased bone strength independent of mineralization 6, while elevated DAAM2 associates with fetal growth restriction through hypoxia-dependent placental dysfunction 7. Recent evidence implicates DAAM2 in bone homeostasis through regulation of immune-mediated senescent osteoblast clearance 8.