DAB1 (Disabled-1) is a critical intracellular signaling adapter in the Reelin-mediated pathway that regulates neuronal migration and brain architecture formation during development 1. DAB1 functions as a docking protein through its phosphotyrosine residues and phosphotyrosine-binding (PTB) domain, mediating intracellular signal transduction downstream of Reelin receptor activation (VLDLR and ApoER2) 2. The Reelin-DAB1 pathway regulates multiple neurodevelopmental processes including neuronal migration, dendritic growth, spine formation, and synaptogenesis 2. Clinically, mutations in DAB1 cause spinocerebellar ataxia 37 (SCA37), an autosomal dominant cerebellar ataxia characterized by progressive neurological dysfunction 3. Beyond ataxia, DAB1 dysfunction is implicated in Alzheimer's disease pathogenesis; disruption of the ApoER2-DAB1 signaling pathway correlates with phosphorylated Tau accumulation and neurodegeneration in sporadic Alzheimer's disease 4. Conversely, Reelin variants enhancing DAB1 activation may provide neuroprotection against Alzheimer's disease 5. DAB1 is also expressed during kidney development and may regulate tubular formation 6, and its expression is suppressed by microbiota-derived propionate, linking gut microbiota to metabolic disease predisposition 7. Additionally, DAB1-mediated Reelin signaling in cerebellar development is hijacked in medulloblastoma metastasis 8.