DAB2IP (DAB2 interacting protein) is a multifunctional scaffold protein and Ras GTPase-activating protein (RasGAP) that regulates diverse signaling pathways controlling cell survival, apoptosis, and growth inhibition 1. As a RasGAP, DAB2IP negatively controls Ras-dependent mitogenic signals and modulates multiple oncogenic pathways including TNFα/NF-κB, WNT/β-catenin, and PI3K/AKT signaling 2. It functions as a critical signaling adaptor by sequestering kinases like AKT1 and MAP3K5, balancing pro-survival and pro-apoptotic signals in response to inflammatory stimuli 2. Additionally, DAB2IP regulates the endoplasmic reticulum unfolded protein response and mediates ER stress-induced JNK activation 3. DAB2IP functions as a potent tumor suppressor frequently downregulated in multiple cancer types through promoter methylation and post-transcriptional mechanisms 1. In pancreatic cancer, DAB2IP overexpression decreases Ras activity, inhibits cell proliferation, and increases chemotherapy sensitivity 4. Similarly, DAB2IP downregulation in gastric cancer enhances cell proliferation and metastasis through ERK1/2 pathway activation 5. In renal cell carcinoma, DAB2IP loss promotes radioresistance by preventing PARP-1 degradation 6. Beyond cancer, DAB2IP regulates trophoblast invasion during placental development and cortical neuron migration during brain development 7. These findings establish DAB2IP reactivation as a promising therapeutic strategy to simultaneously suppress multiple oncogenic pathways across diverse tumor types.