DCDC2C (doublecortin domain containing 2C) is a cytoplasmic protein localized to sperm flagellar structures and microtubule organizing centers. The gene encodes a product with important roles in sperm flagellar microtubule dynamics and organization 1, as demonstrated through integrated genomics analysis validating DCDC2C expression in male germline differentiation. DCDC2C associates with multiple complex diseases through genome-wide association studies. A Chinese multicenter study identified a novel SNP in DCDC2C significantly associated with primary restless legs syndrome (RLS) susceptibility, alongside previously established RLS loci 2. Additionally, variants in DCDC2C showed association with Salmonella susceptibility in pigs, potentially implicating roles in bacterial defense mechanisms including neutrophil recruitment and intracellular bacterial killing 3. Epigenetic analysis revealed DCDC2C loci colocalize with chr2 obstructive pulmonary disease (COPD) genome-wide association signals through DNA methylation quantitative trait loci mechanisms, suggesting genetic control of methylation contributes to COPD pathogenesis 4. Transcriptomic meta-analysis identified DCDC2C among genes showing differential expression in stress response studies, though direct mechanistic roles remain insufficiently characterized 5. Overall, DCDC2C represents a pleiotropic locus with demonstrated importance in sperm motility and emerging associations with neurological, pulmonary, and infectious disease susceptibility.