DDX24 is a DEAD-box RNA helicase that plays critical roles in RNA metabolism and cellular homeostasis, with diverse functions in both normal physiology and disease. The protein is primarily localized to the nucleolus where it regulates ribosome biogenesis and nucleolar homeostasis through interactions with nucleophosmin (NPM1) 1. DDX24 functions as an RNA-binding protein that stabilizes specific mRNAs, including LAMB1 in hepatocellular carcinoma and PPFIA4 in endothelial cells, thereby influencing cellular processes such as mitochondrial function and blood-brain barrier integrity 23. The helicase also acts as a splicing factor, regulating alternative splicing of genes like IKBKG to modulate autophagy pathways 4. DDX24 exhibits context-dependent roles in cancer, promoting progression in hepatocellular carcinoma and non-small cell lung cancer through mRNA stabilization and protein interactions with RPL5, while inhibiting clear cell renal cell carcinoma progression via AKR1B10 regulation 256. Point mutations in DDX24 are associated with vascular malformations, disrupting nucleolar structure and endothelial cell function 1. Additionally, DDX24 serves as a negative regulator of innate immune responses, impeding interferon production during viral infections 7.