HomeAboutRankingsData Sources
Β© 2026 GeneE
🧬
GeneE
0 sources retrieved Β· Most recent: April 2026 Β· Index updated 14 days ago
β“˜GeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
DEFB115
defensin beta 115
Chromosome 20 Β· 20q11.21
NCBI Gene: 245929Ensembl: ENSG00000215547.1HGNC: HGNC:18096UniProt: Q30KQ5
4PubMed Papers
6Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY
βœ“ Experimental GO Evidenceβœ“ Swiss-Prot Reviewed
protein bindingmembrane destabilizing activitykilling of cells of another organisminnate immune responseaortic stenosisrectosigmoid junction neoplasmsmoking initiationliver disease
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

defensin beta 115

⚠Limited data available β€” This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsβ“˜6
aortic stenosisOpen Targets
0.16Weak
rectosigmoid junction neoplasmOpen Targets
0.03Suggestive
smoking initiationOpen Targets
0.03Suggestive
liver diseaseOpen Targets
0.02Suggestive
Miyoshi myopathyOpen Targets
0.01Suggestive
diabetes mellitusOpen Targets
0.00Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar β†—
Related Genes
DEFB135Shared pathway100%DEFB132Shared pathway100%DEFB125Shared pathway100%DEFB121Protein interaction85%DEFB123Protein interaction85%DEFB119Protein interaction85%
Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network
Click a node to explore
DEFB115DEFB135DEFB132DEFB125DEFB121DEFB123DEFB119
PROTEIN STRUCTURE
Preparing viewer…
AlphaFoldAI-predicted Β· UniProt Q30KQ5
View on AlphaFold β†—
Constraintβ“˜
LOEUFβ“˜
1.49LoF Tolerant
pLIβ“˜
0.01Tolerant
Observed/Expected LoF0.80 [0.45–1.49]
RankingsWhere DEFB115 stands among ~20K protein-coding genes
  • #18,546of 20,598
    Most Researched4
  • #15,090of 17,882
    Most Constrained (LOEUF)1.49
Genes detectedDEFB115
Sources retrieved0 papers
Response timeβ€”