DEFB115 — defensin beta 115

4 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

4PubMed Papers

#18,598 · top 96% of 19K genes

6Diseases

top 96%

0Drugs

0Pathogenic Variants

Experimental GO EvidenceSwiss-Prot Reviewed

protein bindingmembrane destabilizing activitykilling of cells of another organisminnate immune responseaortic stenosisrectosigmoid junction neoplasmsmoking initiationliver disease

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

defensin beta 115

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations6

aortic stenosisOpen Targets

0.16Weak

rectosigmoid junction neoplasmOpen Targets

0.03Suggestive

smoking initiationOpen Targets

0.03Suggestive

liver diseaseOpen Targets

0.02Suggestive

Miyoshi myopathyOpen Targets

0.01Suggestive

diabetes mellitusOpen Targets

0.00Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression

No tissue expression data available for this gene.

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt Q30KQ5

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ConstraintgnomAD v4.1

LOEUFⓘ

1.49LoF Tolerant

pLIⓘ

0.01Tolerant

Observed/Expected LoF0.80 [0.45–1.49]

Rankings2 dim

Where DEFB115 stands among ~20K protein-coding genes

#18,546of 20,598
Most Researched4
#15,090of 17,882
Most Constrained (LOEUF)1.49