DEPDC7 (DEP domain containing 7) is a cytosolic protein with emerging roles in cellular signaling and disease pathophysiology. Primary function: DEPDC7 binds to CARMA2 and CARMA3 proteins and regulates NF-κB activation 1. Specifically, DEPDC7 is required to convey signals from activated G protein-coupled receptors to the CBM complex, with shRNA-mediated knockdown impairing NF-κB activation 1. Mechanism: DEPDC7 knockdown in hepatocellular carcinoma cells paradoxically increases cell migration and invasion 2, suggesting complex roles in tumor biology. Disease relevance: DEPDC7 DNA hypomethylation in peripheral blood correlates with depressive symptoms in adult twins, with 10% hypomethylation associated with ~3.1 point increases in depressive symptom scores 3. The gene was identified as a hub gene in fatty acid metabolism-related diagnostic and prognostic models for hepatocellular carcinoma 4. Clinical significance: DEPDC7 appears as a candidate gene in developmental colour agnosia 5 and was identified in a chr11 deletion associated with cryptorchidism and azoospermia 6. DEPDC7 phosphopeptides showed increased frequency in sepsis patients 7. Further investigation is needed to clarify DEPDC7's precise role across these diverse pathological conditions.