DGKB (diacylglycerol kinase beta) is a cytosolic ATP-dependent enzyme that catalyzes phosphorylation of diacylglycerol (DAG) to phosphatidic acid, playing a central role in lipid metabolism and intracellular signaling 1. The enzyme regulates intracellular DAG concentration and influences fatty acid oxidation, with functional relevance in mitochondrial lipid homeostasis 1. Genetically, DGKB variants are robustly associated with glycemic regulation and type 2 diabetes risk. DGKB/TMEM195 locus variants correlate with decreased glucose-stimulated beta cell insulin secretion and impaired glucose homeostasis in population studies 23. Expression quantitative trait loci (eQTL) analysis in pancreatic islets identified DGKB as a colocalized gene variant influencing both T2D susceptibility and glycemic traits 4. Additionally, DGKB rs12666606 shows pleiotropic association with endometriosis and depression through shared genetic mechanisms 5. Clinically, DGKB dysfunction has been implicated in radioresistance in glioblastoma; downregulation promotes tumor cell survival through altered lipid metabolism 1. DGKB variants also associate with peripheral blood stem cell mobilization efficiency, suggesting roles in hematopoietic cell migration 6. Skeletal abnormalities including copy number variations in the ETV1-DGKB region have been associated with osteoporosis pathology 7. These findings position DGKB as a metabolic regulator with multisystem clinical relevance.