DHRS7B is a reductase enzyme located on chromosome 17 that plays crucial roles in lipid metabolism and adipogenesis. It catalyzes conversion of acyl and alkyl dihydroxyacetone-phosphate into glycerolipids and ether lipids, respectively, generating ether-linked phospholipids that serve as PPARG agonists. DHRS7B regulates adipogenesis by preventing brown adipocyte differentiation through nuclear PRDM16 interaction. Based on limited published evidence, DHRS7B participates in PPAR signaling pathway activation during lipid-related metabolic processes 1.