DNAJC11 is a mitochondrial outer membrane protein that plays a critical role in mitochondrial inner membrane organization and cristae formation 12. The protein functions as part of the MICOS (mitochondrial contact site) complex, which is essential for mitochondrial cristae structure and junction formation 12. DNAJC11 associates with multiple mitochondrial protein complexes, including the SAM (sorting assembly machinery) complex and interacts with proteins such as mitofilin, metaxins, and VDACs 23. Beyond structural roles, DNAJC11 regulates mitochondrial distribution by facilitating ARMC1 release from mitochondria, thereby balancing mito-cytoplasmic shuttling and maintaining steady-state mitochondrial distributions 4. The protein contains functionally distinct domains: the DUF3395 domain mediates protein-protein interactions while the J-domain determines mitochondrial localization 3. Mutations in DNAJC11 cause severe neuromuscular pathology in mice, characterized by motor neuron vacuolation, cristae disorganization, muscle weakness, and early lethality 1. The protein is also essential for podocyte cytoskeletal integrity and is regulated by the lncRNA RMRP, which controls DNAJC11 expression to maintain mitochondrial stability 56. DNAJC11 represents a critical component of mitochondrial quality control and cellular energy metabolism.