1 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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26PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
dolichyldiphosphatase activityprotein N-linked glycosylationendoplasmic reticulum membranedolichyl monophosphate biosynthetic processneurodegenerative diseasemetabolic syndromerespiratory system diseasehypersomnia
DOLPP1 (dolichyldiphosphatase 1) is an endoplasmic reticulum membrane enzyme required for efficient N-glycosylation through its role in maintaining optimal dolichol-linked oligosaccharide levels. It catalyzes hydrolysis of dolichyl pyrophosphate at high efficiency and dolichyl monophosphate at lower rates, functioning in the dolichyl monophosphate biosynthetic pathway. Based on limited published evidence, DOLPP1 has been implicated in endometrial cancer, where it was identified as a critical component in a competing endogenous RNA network regulated by LINC00958 through miR-761 1.
1
DOLPP1 identified as critical gene in ceRNA network in endometrial cancer, regulated by LINC00958/miR-761 axis
PMID: 31338870⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
neurodegenerative diseaseOpen Targets
metabolic syndromeOpen Targets
respiratory system diseaseOpen Targets
endometrial cancerOpen Targets
acute myeloid leukemiaOpen Targets
cervical cancerOpen Targets
cholangiocarcinomaOpen Targets
gastric cancerOpen Targets
Hereditary breast cancerOpen Targets
hereditary breast carcinomaOpen Targets
nonpapillary renal cell carcinomaOpen Targets
ovarian serous cystadenocarcinomaOpen Targets
urinary bladder cancerOpen Targets
Uterine CarcinosarcomaOpen Targets
uterine corpus endometrial carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.