DSC1 (desmocollin 1) is a desmosomal cadherin protein that functions as a key component of cell-cell adhesion junctions in epithelial tissues 1. The protein is expressed in differentiated layers of human epidermis and plays a critical role in maintaining epidermal cell adhesion 1. DSC1 serves as a target antigen in autoimmune blistering diseases, particularly as the target of IgA autoantibodies in subcorneal pustular dermatosis-type IgA pemphigus 23. Additionally, IgG autoantibodies against DSC1 are frequently detected in nonclassical pemphigus variants, including paraneoplastic pemphigus, where they may contribute to pathogenesis 4. Beyond its role in skin disorders, DSC1 has emerged as a negative regulator of HDL biogenesis, where it binds apolipoprotein A-I in cholesterol-rich membrane microdomains and inhibits atheroprotective HDL functions 56. In cancer, DSC1 expression is elevated in head and neck squamous cell carcinoma, where higher expression correlates with poor prognosis and promotes tumor cell proliferation and migration through β-catenin signaling pathways 7. The DSC1 gene is located on chromosome 18.1 and comprises 17 exons spanning approximately 33 kb 8.