DSPP (dentin sialophosphoprotein) encodes a crucial protein for dentin formation and mineralization that is processed into two functional components: dentin sialoprotein (DSP) and dentin phosphoprotein (DPP) 1. DPP, the most abundant non-collagenous protein in dentin, contains highly polyanionic repeating sequences of aspartic acids and phosphoserines that promote mineralization by binding calcium and presenting it to collagen fibers at the mineralization front 2. This function is supported by extensive in vitro data showing DPP initiates and modulates hydroxyapatite crystal formation and growth 2. DSPP mutations cause autosomal dominant hereditary dentin disorders including dentinogenesis imperfecta types II and III, and dentin dysplasia type II, with most mutations clustering in the DPP-coding region between nucleotides 1686-2134 345. These disorders present clinically as discolored teeth with structural defects, bulbous crowns, and small pulp chambers, often requiring lifelong dental management 6. Beyond dental tissues, DSPP is expressed in bone, periodontal tissues, and salivary glands, with DSPP-deficient mice showing periodontal defects including furcation involvement and alveolar bone loss 7. Interestingly, DSPP mutations are also associated with progressive hearing loss 1.