Based on limited published evidence, DUSP29 is a dual specificity phosphatase that dephosphorylates phosphotyrosine, phosphoserine, and phosphothreonine residues with phosphotyrosine preference 1. In skeletal muscle, it negatively regulates the ERK1/2-MAPK cascade and modulates muscle cell differentiation 2. DUSP29 is induced during neurogenic muscle atrophy and attenuates glucocorticoid receptor activity while destabilizing AMPK protein 2. The phosphatase localizes to cytoplasm and nucleus, functions in protein homodimerization, and participates in intracellular signaling modulation. However, DUSP29 does not regulate melanoma-myoblast interactions in co-culture models 3.