ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator) is a cell-surface glycoprotein primarily expressed in endothelial cells with critical roles in vascular development and homeostasis. Functionally, ECSCR promotes endothelial cell migration and angioblast migration during vasculogenesis 1 by localizing to actin-rich membrane protrusions 1 and regulating the actin cytoskeleton. ECSCR enhances VEGF receptor 2 (KDR) sensitivity and activation 12, biochemically associating with KDR to facilitate VEGF-induced signaling and promote KDR degradation 2. Additionally, ECSCR modulates endothelial apoptosis through proteasomal degradation of anti-apoptotic proteins BIRC2 and BIRC3. Beyond vascular biology, ECSCR is expressed in white adipocytes where it regulates lipolysis via the PTEN/AKT pathway 3; ECSCR knockout mice exhibit elevated fasting plasma triglycerides. Clinically, ECSCR serves as a tumor endothelial marker; high ECSCR expression during antiangiogenic therapy correlates with prolonged progression-free survival 4. Recent studies identified ECSCR as a signature biomarker for ulcerative colitis diagnosis and drug efficacy assessment, with upregulation correlating with neutrophil levels and inflammatory pathway activation 5. The gene undergoes complex alternative splicing producing multiple functional isoforms 67, suggesting functional complexity in health and disease contexts.