EFEMP2 is an extracellular matrix glycoprotein essential for elastic fiber formation and vascular integrity 1. It facilitates elastic laminae-smooth muscle cell connections in the aorta through promotion of elastin coacervation and deposition onto microfibrils, while regulating collagen and elastin cross-linking via LOX interaction 23. EFEMP2 mediates cell adhesion through heparin binding and modulates vascular smooth muscle cell proliferation and differentiation via angiotensin signaling 4. Loss of EFEMP2 function impairs mechanotransduction and elastic fiber-collagen network integration, causing arterial tortuosity and bone fragility 5. Clinically, biallelic EFEMP2 variants cause autosomal recessive cutis laxa type 1B, characterized by connective tissue laxity, aortic aneurysms, and skeletal abnormalities 6. Beyond genetic disease, EFEMP2 is upregulated in glioblastoma and promotes tumor progression through multiple mechanisms: it enhances glioma cell proliferation, G1/S transition, and invasion via increased MMP-2/MMP-9 expression 7, and functions as a key prognostic marker associated with worse outcomes 8. EFEMP2 also emerges as a shared pathogenic gene in periodontitis and Alzheimer's disease 9, suggesting broader roles in inflammatory and neurodegenerative pathology. These findings indicate EFEMP2 inhibition as a potential therapeutic strategy for gliomas and related conditions.