EGFL7 (EGF like domain multiple 7) is a secreted angiogenic factor that plays crucial roles in vascular development and disease pathogenesis 1. The protein is secreted by endothelial cells and neurons into the extracellular matrix, where it regulates essential biological processes involving blood vessels and the central nervous system 2. EGFL7 promotes sprouting angiogenesis through modulation of NOTCH signaling pathways and maintenance of endothelial integrity 3. In a 3D microvessel model, EGFL7 knockdown suppressed VEGF-A-induced sprouting angiogenesis and impaired barrier function, demonstrating its importance in proper adherens junction formation 3. The protein also regulates angiogenesis through interactions with MAPK, integrin pathways, and EGF receptor cascades 4. EGFL7 has significant disease relevance, being dysregulated in multiple cancer types where it functions as an oncogene, promoting tumor angiogenesis, metastasis, and invasion 14. In hepatocellular carcinoma, EGFL7 expression increases in less differentiated tumors compared to surrounding cirrhotic tissue, suggesting involvement in later oncogenic phases 5. Additionally, EGFL7 has emerged as a potential biomarker in Alzheimer's disease, where angiogenic endothelial cells show increased EGFL7 expression 6, highlighting its therapeutic potential across multiple diseases 2.