EHD3 (EH domain containing 3) is an ATP- and membrane-binding protein that regulates endocytic recycling through membrane tubulation mechanisms. The protein localizes to recycling endosomal tubular structures and controls membrane reorganization upon ATP hydrolysis 1. EHD3 plays critical roles in multiple trafficking pathways, including early endosome to recycling endosome transport, retrograde early endosome to Golgi transport, and rapid recycling from endosomes to plasma membrane 2. The protein's membrane tubulation activity is induced by phosphatidic acid binding, which is essential for proper endocytic recycling function 3. EHD3 undergoes SUMOylation on lysines 315 and 511, which is required for its localization to tubular endocytic recycling compartment structures and efficient transferrin recycling 4. In cardiac tissue, EHD3 expression is consistently increased in heart failure models, suggesting involvement in pathological remodeling 5. EHD3 also functions in early ciliogenesis, where it collaborates with EHD1 to form ciliary vesicles from distal appendage vesicles, representing an essential step in primary cilium assembly 1. Additionally, EHD3 has been associated with cognitive function in major depressive disorder patients 6.