ENKUR (enkurin, TRPC channel interacting protein) is a multifunctional adapter protein that serves critical roles in ciliary biology and tumor suppression. As a microtubule inner protein component of motile cilia, ENKUR is essential for ciliary beating and proper left-right axis patterning during development 1. The protein functions as an evolutionarily conserved ciliary component, with mutations causing situs inversus in humans 1. Beyond its ciliary functions, ENKUR acts as a tumor suppressor across multiple cancer types including endometrial, colorectal, nasopharyngeal, and lung adenocarcinomas 2345. Mechanistically, ENKUR regulates the PI3K/AKT signaling pathway and modulates β-catenin/Wnt signaling through direct protein interactions 23. The protein binds to FBXW7 E3 ligase to promote CTNNB1 ubiquitination and degradation, and interacts with MYH9 to regulate p53 stability and prevent epithelial-mesenchymal transition 24. ENKUR expression is consistently downregulated in various malignancies, correlating with poor prognosis and increased metastatic potential 36. Additionally, ENKUR shows involvement in calcium signaling pathways and may regulate endothelial permeability 7.