ERMARD (ER membrane associated RNA degradation) is a gene located on chromosome 6 that plays a role in neuronal development and brain morphogenesis. While its precise molecular mechanism remains incompletely characterized, ERMARD is implicated in structural brain development based on its involvement in periventricular nodular heterotopia (PNH), a neuronal migration disorder 1. ERMARD variants and deletions have been identified as rare causative factors in PNH, where neurons become ectopically retained along lateral ventricles 2. The 6q27 region containing ERMARD has been identified as critical for normal brain development, with deletions associated with multiple structural brain abnormalities including ventricomegaly, agenesis of corpus callosum, hydrocephalus, and cerebellar malformations 23. Beyond neurological disease, ERMARD has been identified as a candidate gene in congenital heart defects, suggesting broader developmental significance 4. Recent work generating patient-derived induced pluripotent stem cells from individuals with 6q27 deletions encompassing ERMARD provides tools for understanding the molecular basis of 6q27 deletion syndrome, which presents with epilepsy, developmental delay, and metabolic complications 5. Array-based genomic analysis is recommended for diagnostic evaluation of patients with suspected ERMARD-related disorders.