EXOC2 (exocyst complex component 2) is a critical subunit of the octameric exocyst complex that mediates tethering and fusion of exocytic vesicles at the plasma membrane 1. The protein functions in membrane transport machinery essential for vesicle docking and exocytosis, and participates in Golgi-to-plasma membrane transport and cytokinesis 1. EXOC2 localizes to membrane reservoirs preloaded with RAB10-dependent tubular compartments and is recruited during pathogenic invasion to facilitate membrane mobilization 2. Additionally, EXOC2 functions downstream of STING in intracellular DNA-mediated innate immune responses, relocalizing to perinuclear vesicles containing exocyst components during pathogen defense 3. Clinically, pathogenic EXOC2 variants cause severe neurodevelopmental disorders characterized by developmental delay, dysmorphism, cerebellar hypoplasia, brain abnormalities, and epilepsy 1. The disease phenotype correlates with reduced exocytosis and defective primary cilium localization of Arl13b 1. EXOC2 genetic variants are also associated with primary open-angle glaucoma risk in multiple populations, with specific haplotypes correlating with intraocular pressure regulation 45. Furthermore, EXOC2 regulates toxicity of C9ORF72 expanded repeats in ALS/FTD, representing a potential therapeutic target 6.