EXOC3 is a core component of the exocyst complex that mediates vesicle docking and tethering to the plasma membrane during exocytosis 1. As part of this conserved multiprotein machinery, EXOC3 functions in conjunction with SNARE proteins and other exocyst components (including EXOC2) to facilitate membrane fusion and regulated secretion 1. The gene plays roles in multiple cellular processes including mitotic cytokinesis and secretory vesicle trafficking. Clinically, EXOC3 has emerged as a candidate disease modifier across multiple conditions. In cardiovascular disease, EXOC3 variants are associated with coronary artery calcification, potentially through effects on platelet function and hemostasis 2. In colorectal cancer, elevated EXOC3 expression correlates with chemoresistance and poor treatment response, suggesting its involvement in drug efflux or exosome-mediated resistance mechanisms 3. EXOC3 has also been identified as a genetic susceptibility locus for esophageal adenocarcinoma and its precursor, Barrett esophagus 4, and as a modifier of cystic fibrosis lung disease severity 5. Additionally, EXOC3 expression changes were observed in nephrotoxicity responses 6, and DNA methylation at EXOC3 shows age correlation in forensic applications 7. These diverse associations suggest EXOC3 dysfunction may contribute to disease pathogenesis through impaired secretory pathway function.