EXOC7 (exocyst complex component 7) is a core component of the exocyst, an octameric protein complex essential for tethering secretory vesicles to the plasma membrane prior to SNARE-mediated fusion 1. In adipocytes, EXOC7 plays a critical role in insulin-stimulated glucose transporter 4 (GLUT4) translocation by directing vesicles to precise fusion sites on the plasma membrane 2. Beyond metabolic regulation, EXOC7 is essential for neuronal development and survival; homozygous loss-of-function variants cause neurodevelopmental disorder characterized by brain atrophy, seizures, developmental delay, microcephaly, and infantile death 3. In cancer biology, EXOC7 has dual roles: its alternative splicing isoform EXOC7-S promotes trastuzumab resistance in HER2-positive breast cancer via altered immune signaling 4, while EXOC7 enables tumor cell membrane repair following neutrophil-mediated trogocytosis, allowing escape from antibody-dependent cellular cytotoxicity 5. Additionally, EXOC7 transamidation enhances tumor metastasis through promotion of matrix metalloproteinase secretion and invadopodia formation 6. In polyglutamine diseases, EXOC7 modulates proteotoxic stress by regulating ubiquitin-proteasome function 7. These findings establish EXOC7 as a multifunctional protein with critical roles in development, metabolism, and cancer pathogenesis.