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GeneE
25 sources retrieved · Most recent: April 2026 · Index updated 15 days ago
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FABP2
fatty acid binding protein 2
Chromosome 4 · 4q26
NCBI Gene: 2169Ensembl: ENSG00000145384.4HGNC: HGNC:3556UniProt: P12104
223PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
FUNCTIONAL ROLE
Transporter
RESEARCH IMPACT
Trending
DATA QUALITY
✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
intestinal lipid absorptionprotein bindinglong-chain fatty acid bindingfatty acid transportAbnormality of the skeletal systempulmonary embolismcoronary artery diseasethyroid cancer
✦AI Summary

AI summary not yet available. Showing NCBI Gene summary.

fatty acid binding protein 2

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.
Disease Associationsⓘ20
Abnormality of the skeletal systemOpen Targets
0.49Moderate
pulmonary embolismOpen Targets
0.31Weak
coronary artery diseaseOpen Targets
0.26Weak
thyroid cancerOpen Targets
0.19Weak
adolescent idiopathic scoliosisOpen Targets
0.18Weak
obesityOpen Targets
0.15Weak
Myocardial IschemiaOpen Targets
0.12Weak
necrotizing enterocolitisOpen Targets
0.12Weak
COVID-19–associated multisystem inflammatory syndrome in adultsOpen Targets
0.10Weak
SepsisOpen Targets
0.10Weak
type 2 diabetes mellitusOpen Targets
0.10Weak
diabetes mellitusOpen Targets
0.10Suggestive
COVID-19Open Targets
0.10Suggestive
type 1 diabetes mellitusOpen Targets
0.09Suggestive
vein disorderOpen Targets
0.09Suggestive
gestational diabetesOpen Targets
0.09Suggestive
irritable bowel syndromeOpen Targets
0.09Suggestive
coronary atherosclerosisOpen Targets
0.09Suggestive
celiac diseaseOpen Targets
0.09Suggestive
major depressive disorderOpen Targets
0.08Suggestive
Pathogenic Variants
No pathogenic variants reported on ClinVar for this gene.
View on ClinVar ↗
Related Genes
GOT2Protein interaction78%MANBAProtein interaction76%INSIG2Protein interaction73%FABP1Protein interaction68%FABP6Protein interaction62%FABP4Shared pathway50%
Tissue Expression6 tissues
Brain
100%
Liver
67%
Ovary
22%
Lung
11%
Heart
0%
Bone Marrow
0%
Gene Interaction Network
Click a node to explore
FABP2GOT2MANBAINSIG2FABP1FABP6FABP4
PROTEIN STRUCTURE
Preparing viewer…
PDB3AKM · 1.90 Å · X-ray
View on RCSB ↗
Constraintⓘ
LOEUFⓘ
1.34LoF Tolerant
pLIⓘ
0.16Tolerant
Observed/Expected LoF0.53 [0.24–1.34]
RankingsWhere FABP2 stands among ~20K protein-coding genes
  • #1,829of 20,598
    Most Researched223 · top 10%
  • #14,038of 17,882
    Most Constrained (LOEUF)1.34
Genes detectedFABP2
Sources retrieved25 papers
Response time—
📄 Sources
25▼
1
Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression.
PMID: 28814485
Gut · 2018
1.00
2
HNF4 Regulates Fatty Acid Oxidation and Is Required for Renewal of Intestinal Stem Cells in Mice.
PMID: 31759926
Gastroenterology · 2020
0.96
3
Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial.
PMID: 36615801
Nutrients · 2022
0.92
4
Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes.
PMID: 36448480
Circ Res · 2023
0.88
5
PMID: 40484632
Gut · 2025
0.84