FAM110B is a centrosome and spindle pole-associated protein with emerging roles in cancer progression. The protein localizes to centrosomes and the microtubule organization center during interphase, and to spindle poles during mitosis 1. Ectopic expression of FAM110B impairs cell cycle progression in the G1 phase 1. FAM110B functions in multiple cancer contexts: in pancreatic adenocarcinoma, FAM110B expression decreases with increasing tumor differentiation grades and associates with patient survival time 2. In castration-resistant prostate cancer, FAM110B emerges as a key growth-promoting gene that regulates androgen receptor signaling and is itself regulated by androgens; FAM110B knockdown inhibits prostate cancer cell proliferation, particularly under androgen-deficient conditions, and ectopic expression induces aneuploidy 3. FAM110B has also been identified as an immune-related hub gene in pancreatic cancer 4, colon cancer 5, and bladder cancer 6, where it contributes to prognostic models and immune microenvironment composition. Additionally, FAM110B methylation serves as a plasma biomarker for lymphoma detection 7. These findings suggest FAM110B promotes cancer progression through multiple mechanisms involving cell cycle regulation, androgen signaling, and immune modulation, positioning it as a potential therapeutic target across multiple cancer types.