FAM120A is a multifunctional RNA-binding protein and transcriptional co-activator with roles in cell growth, lipid metabolism, and chemotherapy resistance. Mechanistically, FAM120A functions as a scaffolding protein in oxidative stress signaling by regulating SRC family kinase activation and PI3-kinase phosphorylation 1. In anabolic pathways, FAM120A acts as a transcription co-factor downstream of mTORC1 signaling, bridging lipogenic transcription factor SREBP1 to RNA splicing machinery (SRSF1, U1-70K) to enhance synthesis and stability of lipid metabolism enzyme transcripts 2. FAM120A binds and stabilizes specific mRNAs and long non-coding RNAs; it enhances SLC7A11 mRNA stability in gastric cancer 3 and stabilizes MALAT1 in lung cancer 4, both promoting chemotherapy resistance. Additionally, FAM120A competes with Pumilio proteins for mRNA binding sites and impairs RNA interference activity when localized to the nucleus [PMID:39470700; 50]. Disease relevance includes genetic associations with irritable bowel syndrome 6, obesity 7, and cancer chemoresistance in gastric and lung malignancies. FAM120A represents a therapeutic target for overcoming cisplatin resistance in cancer patients.