FAM120B (family with sequence similarity 120 member B) is a transcriptional regulator that functions as a transactivator of PPARG and ESR1, playing a role in adipogenesis through PPARG activation. The protein is involved in peroxisome proliferator activated receptor signaling pathways and fat cell differentiation processes. FAM120B has emerged as a potential therapeutic target in neurodegenerative diseases, with genetic studies identifying it as a causal mediator whose altered brain protein abundance may influence multiple sclerosis (MS) risk 1. In MS pathogenesis, FAM120B expression is significantly dysregulated, showing upregulation in both white matter lesions and normal appearing white matter, with this dysregulation confirmed at the transcriptional level 2. The gene is located within a chr6 region (6q26-27) that has been linked to disease susceptibility across multiple conditions, including visceral leishmaniasis and type 1 diabetes 34. Additionally, FAM120B is part of a 25-gene prognostic signature for ovarian cancer survival prediction 5. The gene's involvement in diverse pathological processes suggests it may serve as both a disease biomarker and potential therapeutic target, particularly in neuroinflammatory conditions like MS.