FAM47E (Family with Sequence Similarity 47 Member E) is a chr4-associated protein that promotes histone methylation through regulation of the arginine methyltransferase PRMT5. Mechanistically, FAM47E interacts with PRMT5 to enhance its chr4 association and histone methylation activity while stabilizing PRMT5 by inhibiting its proteasomal degradation 1. This interaction affects the expression of PRMT5 target genes and regulates cellular colony-forming capacity 1. Clinically, FAM47E has emerged as a disease-associated locus across multiple neurodegenerative and renal conditions. Genetic variants at the FAM47E locus are associated with Alzheimer's disease risk in the Japanese population 2 and correlate with Parkinson's disease age at onset 3, with copy number losses identified in familial PD patients 4. The locus also shows associations with kidney function markers, particularly eGFR and serum magnesium levels, with expression of FAM47E correlating with renal function in both tubule and glomerular compartments 56. Additionally, FAM47E variants have been identified in exploratory genetic analyses of autism spectrum disorder and developmental disorders 7. However, a specific FAM47E SNP (rs6812193) showed no significant association with Parkinson's disease in a Chinese Han population 8, suggesting ethnic variation in genetic susceptibility.