FANCM is a DNA-dependent ATPase that functions as a master coordinator of DNA replication stress responses and genome maintenance 1. As a core component of the Fanconi anemia (FA) pathway, FANCM facilitates monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, enabling cellular resistance to DNA cross-linking agents and prevention of chr14 breakage 2. FANCM possesses specialized ATP-powered branchpoint translocation activity that enables binding and remodeling of diverse DNA structures including double-stranded DNA, fork-structured DNA, Holliday junctions, and single-stranded DNA substrates 1. This helicase activity supports multiple genome maintenance functions: promoting fork reversal, facilitating replication traverse of interstrand crosslinks, resolving R-loop structures, and restraining inappropriate recombination 31. FANCM deficiency causes chromosome 14 and cancer susceptibility, with demonstrated synthetic lethality interactions with SMARCAL1 that produce severe genome instability at simple repeat-rich loci 45. Clinically, FANCM mutations associate with premature ovarian failure and male infertility through meiotic dysfunction 67, while germline variants increase susceptibility to multiple cancer types 2.